Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During ...

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

For almost 60 years, scientists have tried to understand why DNA doesn't replicate wildly and uncontrollably every time a ...

A research team has identified a new mechanism that controls DNA’s ability to replicate—and thereby a cell’s ability to divide.