New study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most ...

研究团队进一步对接受放化疗的癌症患者进行了数据分析，结果显示，USP7 高表达的患者，其肿瘤中浸润淋巴细胞更少，疾病进展更快。而使用 USP7 抑制剂药物可有效降低 TREX1 水平，在放疗后使用该抑制剂，可以成功恢复 cGAS-STING 信号通路的激活，增强抗肿瘤免疫反应。

This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Dr Liu is a ...

这些发现阐明了将DNA损伤与免疫激活联系起来的机制，并强调了USP7抑制剂作为放射免疫治疗的潜在增强剂。 癌细胞中cGAS-STING信号的激活需要由内在或治疗诱导的DNA损伤产生的胞质DNA。然而，利用这种途径来改善免疫疗法的临床努力取得了有限的成功，突出了对 ...

CDT1 inhibits the helicase activity of the MCM complex, thereby suppressing nascent strand synthesis in DNA replication in cultured human cells. This action results in fork collapse and DNA damage, ...

By targeting proteins used to splice genes, UC San Diego researchers have unlocked a new approach to treating triple-negative ...

Colorectal cancer is one of the most prevalent tumors and a leading cause of cancer-related mortality. Despite advances ...

A new study uncovers how working at 35,000 feet may disrupt DNA repair and immune function in flight attendants, offering fresh insights into the health risks faced by cabin crews and the urgent need ...