Chromosomal aberrations, encompassing both structural and numerical chromosome abnormalities, are fundamental indicators of genomic instability with far‐reaching implications for cancer risk. These ...

Healthy cells work hard to maintain the integrity of our DNA, but occasionally, a chromosome can get separated from the others and break apart during cell division. The tiny fragments of DNA then get ...

Translocations, in genetics, happen when chromosomes break and the pieces attach to other chromosomes. This mixing of genetic material has important results. The resultant chromosomes are lacking in ...

A prospective comparison of ER, PR, Ki67 and gene expression in paired sequential core biopsies of primary, untreated breast cancer. This is an ASCO Meeting Abstract from the 2015 ASCO Annual Meeting ...

Genetic disorders can occur due to mutations in one gene (monogenic), multiple genes (multifactorial inheritance), and mutation in one or more chromosomes. Point mutations are where one nucleotide in ...

Patterns of distant metastases in HPV-positive head and neck squamous cell carcinoma. This is an ASCO Meeting Abstract from the 2014 ASCO Annual Meeting I. This abstract does not include a full text ...

It is crucial in the development of cell and gene therapies to understand the impact of the gene editing process on chromosomal structure. When cells are edited, differentiated, modified, or ...

A new test quickly and easily identifies when sperm are carrying chromosomal mutations, and could be applied for men hoping to have children. Chemotherapy and radiation treatments are known to cause ...

The spectrum of information that can be obtained by prenatal testing is wide and rapidly increasing. Many mutations, or "abnormalities," are inconsequential, while others are significant. Genetic ...